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Research Methylparaben, bisphenol A (BPA) and breast cancer

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Parabener påvirker effekten av kreftmedisiner, gir dårligere sedkvalitet og påvirker celler i kroppen

(SFGate Tuesday, September 13, 2011) Forsker Dr. William Goodson III er hovedforfatter av en studie fra California Pacific Medical Center i San Francisco som viser to kjemikalier som er vanlige i forbrukerprodukter – bisfenol-A og metylparaben – forårsaker friske celler til å vokse og overleve som kreftceller og kan forstyrre effektiviteten av anti-kreft medikamenter. Det er en økende mengde bevis ser på de negative helseeffekter av BPA, en plast herding kjemikalie som finnes i mat containere, bokser m.fl. produkter av plast og selv salg kvitteringer, samt Methylparaben, en mindre kjent konserveringsmiddel som finnes i kosmetikk og hygieneprodukter. Vitenskapelige studier har knyttet kjemikalier til hormonelle problemer og reproduktive helsespørsmål, blant andre problemer. Forskerne tok friske ikke kreftsyke celler fra bryster fra pasienter med høy risiko for kreft, odlet dem i et laboratorium og fant ut at når cellene ble utsatt for bisfenol A og Methylparaben, begynte de å oppføre seg som kreftceller.

Forskningen publisert online i det medisinske tidsskriftet Carcinogenesis.

Les forskningesrelultaten: Goodson WH et al (2011)  : ACTIVATION OF THE mTOR PATHWAY BY LOW LEVELS OF XENOESTROGENS IN BREAST EPITHELIAL CELLS FROM HIGH-RISK WOMEN

Mer om emnet
Andre forskere har funnet:

(PubMed.gov År 2008) Rapport om sikkerhetsvurdering av Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, og Benzylparaben som brukes i kosmetiske produkter.

Parabener er navnet gitt til en gruppe av p-hydroksybenzosyre (PHBA) estere som brukes i over mange titusentall kosmetiske produkter som konserveringsmidler ved konsentrasjoner opp til 0,8% (blandinger av parabener) eller opp til 0,4% (enkelt paraben). Gruppen omfatter Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, og Benzylparaben. Industri anslag over den daglige bruken av kosmetiske produkter som kan inneholde parabener var 17,76 g for voksne og 378 mg for spedbarn.

Paraben lagres ikke i kroppen, når du slutter å bruke det synker mengden langsomt fra kroppen. Parabener i kosmetiske formuleringer påføres huden penetrerer stratum corneum. Carboxylesterases hydrolyserer parabener i huden. Parabener akkumuleres ikke i kroppen. Serumkonsentrasjonen av parabener, selv etter intravenøs administrering, avtar raskt og holder seg lav.

  • Parabener er ikke funnet giftige.
  • Propylparaben, og Butylparaben påvirker antall spermier på alle nivåer fra 0,01% til 1,0% og redusert spermeantall og bevegelige aktivitet i avkom.
  • Ethylparaben og Methylparaben medførde økt kromosomavvik.
  • Ethylparaben, Propylparaben, og Butylparaben i kosten produserte celleproliferasjon i formagen.

Int J Toxicol. 2008;27 Suppl 4:1-82. doi: 10.1080/10915810802548359

In English

Parabens affect the efficacy of cancer drugs, leed to poorer semen quality and affects cells in the body

(SFGate Year 2011) Scientist Dr. William Goodson III is the lead author of a study by  from California  Pacific Medical Center in San Francisco that shows two chemicals common in consumer  products – bisphenol-A and methyl paraben – cause healthy cells to grow and  survive like cancer cells and can interfere with the effectiveness of  anti-cancer drugs. There is a growing body of evidence looking at the negative health effects of BPA, a  plastic hardening chemical found in food containers, cans and even sales  receipts, as well as methylparaben, a lesser-known preservative found in  cosmetics and personal care products. Scientific studies have linked the chemicals to hormonal problems and  reproductive health issues, among other problems. Researchers took noncancerous breast cells from high-risk patients, grew them in  a laboratory and found that once the cells were exposed to bisphenol A and  methylparaben, they started behaving like cancer cells.

Research is published online in the medical  journal Carcinogenesis.

Read research: Goodson WH et al (2011)  : ACTIVATION OF THE mTOR PATHWAY BY LOW LEVELS OF XENOESTROGENS IN BREAST EPITHELIAL CELLS FROM HIGH-RISK WOMEN

Read more: sfgate.com

More on the subject
Other researchers found:

(PubMed.org year 2008) Report on the safety assessment of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben as used in cosmetic products.

Parabens is the name given to a group of p-hydroxybenzoic acid (PHBA) esters used in over many thousand cosmetics as preservatives at concentrations up to 0.8% (mixtures of parabens) or up to 0.4% (single paraben). The group includes Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben. Industry estimates of the daily use of cosmetic products that may contain parabens were 17.76 g for adults and 378 mg for infants.

Paraben do not store in the body, when you stop using it fades away from your body. Parabens in cosmetic formulations applied to skin penetrate the stratum corneum. Carboxylesterases hydrolyze parabens in the skin. Parabens do not accumulate in the body. Serum concentrations of parabens, even after intravenous administration, quickly decline and remain low.

  • Parabens are not found toxic.
  • Propylparaben, Butylparaben did affect sperm counts at all levels from 0.01% to 1.0% and decreased sperm number and motile activity in offspring.
  • Ethylparaben and Methylparaben did increase chromosomal aberrations.
  • Ethylparaben, Propylparaben, and Butylparaben in the diet produced cell proliferation in the forestomach.

Int J Toxicol. 2008;27 Suppl 4:1-82. doi: 10.1080/10915810802548359

Author: Annelie

I like canoeing, photographing, friends, movies, food, humor, and going on trips. I dislike rudeness, dishonesty, violence, nastyness, and people not caring for others. I do not drink much, I do not smoke and I do not do drugs. I love friends who are kind to me and stick with me. If you want to give me a gift, the best gift is to stop smoking and stop using fragranced products. Then you give me health and that dear friend, is the best gift a person can get. It is a gift of love. I got asthma and I am hearing disabled.

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