Alpha 1 Antitrypsin deficiency
I found some really good videos on YouTube.com about Alpha 1 Antitrypsin deficiency. This is about Alpha 1, but the first part also describes the sensation having asthma without Alpha 1. So to understand the nature of asthma you really need to see the first part of the video. Note! that asthma and Alpha 1 Antitrypsin deficiency is not the same even though the experience of the symptoms are in many ways much similar.
Part 1 show you what it feels like having Alpha 1 Antitrypsin deficiency, but also what it feels like having asthma even though asthma and Alpha 1 Antitrypsin deficiency is not the same.
Part two show you the real severity view of Alpha 1
Good Reading on Alpha 1 Antitrypsin deficiency
There are many with Alpha 1 also has some form of asthma, others have bronchiestase, fibrosis, cyatisk fibrosis, chronic bronchitis, etc. Many people experience emphysema early in life because of its Alpha 1. It is often when you have emphysema you get infusion therapy.
Alpha-1 Antitrypsin Deficiency (Alpha-1) is a genetic (inherited) condition – it is passed from parents to their children through their genes. Alpha-1 may result in serious lung disease in adults and/or liver disease at any age.
For each trait a person inherits, there are usually two genes; one gene comes from each parent. People with Alpha-1 have received two abnormal alpha-1 antitrypsin genes. One of these abnormal genes came from their mother and one from their father.
Alpha-1 occurs when there is a lack of a protein in the blood called alpha-1 antitrypsin, or AAT. AAT, the alpha-1 protein, is mainly produced by the liver. The main function of AAT is to protect the lungs from inflammation caused by infection and inhaled irritants such as tobacco smoke.
Source and Read more: http://alpha-1foundation.org/what-is-alpha-1/
Because Alpha-1 is genetic, Alpha-1 lung disease is commonly called “genetic COPD.” People with Alpha-1 lung disease have two abnormal genes (one from each parent). The most common abnormal genes are called Z and S genes.
Early diagnosis of Alpha-1 is very important because quitting smoking (if the Alpha smokes) and early treatment are both essential to help slow the progression of Alpha-1 lung disease.
However, Alpha-1 Antitrypsin Deficiency can’t be diagnosed by symptoms or by a medical examination alone; you need to get a blood test to know for sure.
Alpha-1 is often first diagnosed as asthma or smoking-related Chronic Obstructive Pulmonary Disease (COPD). COPD includes emphysema and chronic bronchitis. Alpha-1 is the most common genetic risk factor for COPD. About 3 percent of all people diagnosed with COPD may have undetected Alpha-1.
The World Health Organization (WHO), American Thoracic Society (ATS), and the European Respiratory Society (ERS) recommend that everyone with COPD, bronchiectasis, or asthma that isn’t controlled with usual medications, be tested for Alpha-1.
Source and Read more: http://alpha-1foundation.org/about/
There is no cure for Alpha-1 lung disease, but treatments are available.
Alphas with lung diseases such as asthma, COPD or bronchiectasis can be helped by the same drugs used by non-Alphas for these conditions.
These include drugs to open up the lung passages (bronchodilators) and reduce the chronic inflammation that is common in the lungs of Alphas (corticosteroids).
Since infections in the lung can bring millions of extra white blood cells into the lungs, many doctors who care for Alphas recommend that lung infections be treated early and aggressively with antibiotics. One sign of a lung infection is when the Alpha starts to cough up mucus or phlegm that is yellow or green in color.
Besides the usual treatments for COPD in general, there is a specific therapy available to Alphas with lung disease.
Augmentation therapy consists of intravenous infusions, usually weekly, of alpha-1 antitrypsin protein purified from healthy plasma donors. The goal is to increase the level of alpha-1 protein in the blood and lungs in order to slow or stop the progression of Alpha-1 lung disease.
Augmentation therapy has been shown to increase blood and lung levels of alpha-1 antitrypsin protein, reduce the rate of decline of lung function, and improve survival.
Augmentation therapy cannot restore lost lung function and is not considered a cure. However, this therapy is currently the standard of care for Alphas with COPD.
Source and Read more: http://alpha-1foundation.org/augmentation-therapy/
Neither medicine or transfusion Cure Alpha 1 Antitrypsin deficiency. In the end all having Alpha 1 Antitrypsin deficiency die. To survice they need to have a lung transplant.
But the medicine and the transfusion help those having Alpha 1 Antitrypsin deficiency live longer.
Article is written With help of a friend having Alpha 1 Antitrypsin deficiency and my own knowledge in normal asthma. Please contact www.alpha-1foundation.org for more Information on Alpha 1 Antitrypsin deficiency.
Fact Source: my friend having Alpha 1 and www.alpha-1foundation.org