Guidelines for severe asthma
europeanlung.org 12.12.2013 “A new guideline has provided an updated definition of severe asthma along with new recommendations for treating the condition.
Produced by a joint task force of the European Respiratory Society and the American Thoracic Society, the guideline is published online today (12 December 2013) in the European Respiratory Journal.
Although severe asthma is estimated to account for less than 10% of all asthmatics, these patients have the greatest burden and require a disproportionate amount of healthcare costs to be spent on treating their condition, which is harder to control.
The guideline defines severe asthma as “asthma which requires treatment with high dose inhaled corticosteroids (ICS) plus a second controller (long acting β2 agonist (LABA), leukotriene modifier, theophylline or systemic corticosteroids) to prevent it from becoming uncontrolled or which remains uncontrolled despite this therapy.”
The definition is intended to help doctors to confirm a diagnosis of severe asthma and address associated factors that could be making asthma difficult to treat.
The guideline provides a detailed discussion of the classification (phenotyping) of patients with severe asthma as evidence suggests that severe asthma affects people in different ways.
Recent research has started to group severe asthma into different types (or phenotypes) based on clinical and certain biological features of the condition. These findings can help researchers develop targeted treatments for this group of people whose asthma remains difficult to treat despite taking the recommended therapies. The guideline encourages continuing research into phenotyping severe asthma and finding more effective treatments aimed particularly at specific phenotypes of severe asthma.”
Title: International ERS/ATS Guidelines on Definition, Evaluation and Treatment of Severe Asthma Authors: Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, Adcock IM, Bateman ED, Bel EH, Bleecker ER, Boulet L-P, Brightling C, Chanez P, Dahlen S-E, Djukanovic R, Frey U, Gaga M, Gibson P, Hamid Q, Jajour NN, Mauad T, Sorkness RL, Teague WG DOI: 10.1183/09031936.00202013
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