Fresh air does not smell of fragrance

Frisk luft lukter ikke av parfyme.

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Forskning og påvirkningsnivå ved astma – Research and level of reaction for asthma

Translate: (Go to English version)

Påvirkningsgrad for personer med astma

0,02 PPM (parts mer million, milliondeler)


National Academy of Sciences and National Research Council Washington DC USA 26. November 1965

Just denne undersøkelsen gjelder TDI som er en kjemikalie, men det er en pekepinn på hvor lite som skal til for å utløse et astmaanfall.

“Industrial exposure to TDI vapors has resulted in many cases of allergic reactions involving the respiratory tract with symptoms of asthma. The Threshold limit value of 0,02 PPM is believed to prevent sensitization but may not be low enough to prevent asthmatic attacks in sensitized individuals.” Ph.D Harry W. Hays National Academy of Sciences and National Research Council Washington DC USA 26. November 1965

Parfymer er også kjemikalier, så ikke tro de er trygge. Å ha astma er som å være et levende, gående brannalarm. Vi vet når noe er i luften som ikke er god fisk. Våre lungene reagerer på det, og protesterer. Vi får pustevansker.

In English

0,02 PPM a level for asthma attacks

Since 1965 the level for developing a asthma attack is stated to be 0,02 PPM (Parts Per Million).


National Academy of Sciences and National Research Council Washington DC USA 26. November 1965

This research shown here is specifically about TDI chemical but it actually shows how little is needed to start a asthma attack. 0,02 PPM

“Industrial exposure to TDI vapors has resulted in many cases of allergic reactions involving the respiratory tract with symptoms of asthma. The Threshold limit value of 0,02 PPM is believed to prevent sensitization but may not be low enough to prevent asthmatic attacks in sensitized individuals.” Ph.D Harry W. Hays National Academy of Sciences and National Research Council Washington DC USA 26. November 1965

Fragrances is chemicals too, so do not believe they are safe. Having asthma is like being a living, breathing, walking fire alarm. We know when something fishy is in the air. Our lungs react to it, and protest. We get breathing problems.

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Research: Smoke reduces HDAC2 in the body decreasing effect from medicines.

Smoke damage the effect of Asthma medicine

It is known that passive smoking worsens asthma symptoms and reduce the effectiveness of inhaled steroid treatment, but how this occurs has not been elucidated.

Now researchers at Imperial College in London found that a person with severe asthma who is constantly exposed to smoke, have lower levels of the enzyme HDAC2 compared to those who is not subjected to smoke. It is precisely HDAC2 necessary to steroids in asthma medicine should be able to have an anti-inflammatory effect.

Researchers at Imperial College in London found that children with severe asthma with a parent who smoke at home have lower levels of the enzyme compared with those whose parents do not smoke. HDAC2 is required to steroids in asthma medicine to be able to have an anti-inflammatory effect.

So if you smoke, or if you have asthma, and are around a smoker or a person having asthma, know that it will damage the effect of the asthma medicine.

Don’t smoke. And stay away from smokers!


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Chemical exposure before birth

“The established Western medicine and the FDA is true (Food and Drug Administration, the U.S. Food and Drug Administration also is about drugs, vert.) Warn regularly presumed dangers of alternative medicines and dietary supplements, but they never talk about the widely used and perfectly legal chemical toxins that invade our bodies through the environment. And there’s more, the American nature there is little to do for many of these chemicals that threaten the health, to ward off common consumer products. Now, two new studies have shown that many children breathing problems could have caused by this common chemical threats.

A good example is that by researchers at the Columbia Center for Children’s Environmental Health (the CCCEH), working at the Mailman School of Public Health and Columbia University Medical Center, has shown that children who have been exposed before birth to the widely used pesticide ingredient piperonlybutoxide (PBO) have a greater chance that they have chronic cough at the age of five and six years. Their research, which was recently published in the online edition of the journal Environment International, provides evidence that the lungs of children are susceptible to damage by toxins while children are still in the womb. The problems are not the result of an infection, but chronic cough in children, the normal daily activities of the children quite upset and they also disrupt the sleep of both the children and their parents. But what exactly PBO? It is a chemical that enhances the effects of pyrethroids, substances used in pesticides that are most used by both professional pest control operators as well as consumers, according to a survey by researchers at the Mailman School from 2011. Previous research had shown that exposure to any of the pyrethroids, in particular a variant of the fabric permethrin, was in particular related to the occurrence of cough at the age of five years. The new research shows that children who are pregnant have come up with PBO contacted had an increased risk of cough that were not related to colds or flu. A chemical cause of asthma in children? Another new study by the CCCEH shows an even see much more serious problem, that the ability of children to get free breath can hamper. It appears that children who are exposed to diethyl phthalate (DEP) and benzyl butyl phthalate (BBP), substances belong to chemical group phthalates, which are widely used in personal care products and plastic objects, have an increased risk of infections airways that are related to asthma. research team examined 244 children aged between five and nine years old and found that phthalates in urine were detectable in all children. The children with the highest concentration in their urine of both phthalates had a higher concentration of nitric oxide in their exhaled air, which is a biomarker for airway inflammation. The link between exposure to GDP and airway inflammation was especially strong among children who had recently had shown, wheezing a common symptom of asthma. “Although there are many factors that contribute to the development of asthma, our research shows that phthalates a play an important role, “says Allan Just, PhD, first author of the new study recently published online in the American Journal of Respiratory and Critical Care Medicine. It’s hard to protect your children from phthalates because the manufacturers allowed them use, including plastic, vinyl flooring and body care products. countless consumer products We get phthalates in with our food and inhalation. They can also be absorbed through the skin. Except that they are likely to cause in children, asthma is of different phthalates known that they may cause, the neurological and behavioral problems may impair fertility and may cause eczema in the Author: The work of author Sherry Baker is in many publications, including Newsweek, Health, the Atlanta Journal and Constitution, Yoga Journal, Optometry, Atlanta, Arthritis Today, Natural Healing Newsletter, OMNI, UCLA’s “Healthy Years” newsletter , Mount Sinai School of Medicine’s “Focus on Health Aging” newsletter, the Cleveland Clinic’s “Men’s Health Advisor” newsletter and many others.”  14 March 2014 Source: Natural News Translate: Google Translate

My Source:


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Guidelines for severe asthma –

Guidelines for severe asthma 12.12.2013 “A new guideline has provided an updated definition of severe asthma along with new recommendations for treating the condition.

Produced by a joint task force of the European Respiratory Society and the American Thoracic Society, the guideline is published online today (12 December 2013) in the European Respiratory Journal.

Although severe asthma is estimated to account for less than 10% of all asthmatics, these patients have the greatest burden and require a disproportionate amount of healthcare costs to be spent on treating their condition, which is harder to control.

The guideline defines severe asthma as “asthma which requires treatment with high dose inhaled corticosteroids (ICS) plus a second controller (long acting β2 agonist (LABA), leukotriene modifier, theophylline or systemic corticosteroids) to prevent it from becoming uncontrolled or which remains uncontrolled despite this therapy.”

The definition is intended to help doctors to confirm a diagnosis of severe asthma and address associated factors that could be making asthma difficult to treat.

The guideline provides a detailed discussion of the classification (phenotyping) of patients with severe asthma as evidence suggests that severe asthma affects people in different ways.

Recent research has started to group severe asthma into different types (or phenotypes) based on clinical and certain biological features of the condition. These findings can help researchers develop targeted treatments for this group of people whose asthma remains difficult to treat despite taking the recommended therapies. The guideline encourages continuing research into phenotyping severe asthma and finding more effective treatments aimed particularly at  specific phenotypes of severe asthma.”

Full guideline:

Title: International ERS/ATS Guidelines on Definition, Evaluation and Treatment of Severe Asthma Authors: Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, Adcock IM, Bateman ED, Bel EH,  Bleecker ER, Boulet L-P, Brightling C, Chanez P, Dahlen S-E, Djukanovic R, Frey U, Gaga M, Gibson P, Hamid Q, Jajour NN, Mauad T, Sorkness RL, Teague WG DOI: 10.1183/09031936.00202013

Click the links below to read more:

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Asthma in the 20 when mother exposed during pregnancy

“Children exposed in the womb to two chlorinated chemicals widely found in the environment are more likely to develop asthma by the age of 20, according to new research in Denmark. The study is the first to link asthma to hexachlorobenzene exposure during fetal development, and builds on two earlier studies that linked the respiratory disease to polychlorinated biphenyls.

The study is the first to link asthma to hexachlorobenzene exposure during fetal development, and builds on two earlier studies that linked the respiratory disease to polychlorinated biphenyls.”

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We should throw cleaning spray bottle

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Vi bør kaste rengjøringssprayflasken


Kaste alle sprayflasker og rengjør med såpe, klut og vann.

I dag leste jeg noe på nett i NRK Telemark at forskere og legestanden har komt fram til at man ikke bør bruke rengjøringsmedler på sprayflaske. Dette er noe jeg har advart mot i 6 år. Men det er jo meget godt at de endelig har komt fram til den samme konklusjonen som jeg gjorde etter å ha blitt astmatisk som yrkesskade i 2007. I jobben brukte jeg hyppig forskjellige medler på sprayflaske og annen aerosol form.

I artikkelen kan vi lese:

“Vaskemidler på spray gir astma hos renholdere. Nå skal det undersøkes om også vaskingen hjemme kan gi astma og lungeskader.

Mens proffe renholdere bevisst unngår spray, er bruken økende hjemme hos folk.

– Vi tynner vel sjeldent ut. Vi bruker det vi kan få kjøpt og vi sprayer mer og mer. Dermed puster vi inn mer av disse midlene, sier prosjektleder Anne Kristin M. Fell ved Sykehuset Telemark.

– Vi bør kaste den sprayflasken og heller bruke en klut, sier hun.

Astma vil bli den tredje største dødsårsaken om få år. Nå vil sykehuset finne ut hvor utsatt folk er hjemme.”

De holder på med en stor undersøkelse i Telemark for å finne ut av hva som årsaker astma hos folk, og de har nå funnit ut at sprayflasken er farlig.

Og igjen, jeg er helt enig, akkurat som jeg har ment i 6 år nå. Kutt ut sprayflasken og gå parfymefri folkens!

(NB! Dette er ikke knyttet til et spesielt rengjøringsmerke, men gjelder alle rengjøringsmedler på sprayflaske. )

Kilde: Nrk Telemark

In English

We should throw cleaning spray bottle


Throw away all spray bottles and clean using a cloth, soap and water.

Today I read something online in Norwegian NRK Telemark that scientists and the medical profession made ​​concessions to the conclusion that one should not use cleaning agents on a the spray bottle. This is something I have warned about for 6 years now! But it’s very good that they have finally come up to the same conclusion I did after becoming asthmatic as occupational injuries in 2007. In my job, I frequently used different Cleaners on spray bottle and other aerosol form.

In the article we read:

“Washing the spray and asthma in cleaners. Should now be examined whether also washing at home can cause asthma and lung damage.

While pro cleaners deliberately avoids spray, its use increasing in people.

– We thinner rarely out. We use what we can buy and we spray more and more. Thus we breathe in more of these funds, says project manager Anne Kristin M. Fell at Telemark Hospital.

– We should throw the spray bottle and either use a cloth, she said.

Asthma will be the third leading cause of death in a few years. Now the hospital will determine how vulnerable people are at home. “

They’re on a major study in Telemark to find out what causes asthma in people, and they have now found out the spray bottle is dangerous.

And again, I completely agree. As I have for 6 years. Cut out the spray bottle and go fragrance free guys!

(Note! This is not Attached to any specific brand, but all cleaning using a spray bottle.)

Source: Nrk Telemark

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Fastfood increases risk for asthma, rhinitis and eczema

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Astma Allergi Danmark 08.05.2013. Nytt om Astma Forskning 

Hurtigmat øker risikoen for alvorlig astma, rhinitis og eksem

Det kommer ikke som noen noen nyhet for de fleste at hurtigmat er usunt, men at det kan øke risikoen for astma, rhinitis og eksem er kanskje en nyhet for de fleste?

En stor internasjonal studie fra The University of Auckland (The to ledende forfattere, Professor Innes Asher og Philippa Ellwood) viser at det er en økt risiko for alvorlige astma, eksem og høysnue symptomer (rhinitis) hos barn og ungdom som spiser hurtigmat tre eller flere ganger i uken. Spiser du derimot frukt tre eller flere ganger i uka kan beskytte mot alvorlig astma.

Studien konkluderer med at dersom den observerte korrelasjonen er funnet å være pålitelig, slik at resultatene har stor betydning for folkehelsen på grunn av et økende forbruk av hurtigmat (fastfood) globalt.

Der blev innsamlet data på mere end 319.000 tenåringer (13-14 årsalderen) fra 107 sentere i 51 land, og mere enn 181.000 barn (6-7 år) fra 64 sentre i 31 land. Undersøkelsen spurte om deltakernes inntak av kjøtt, fisk, frukt og grønnsaker, belgfrukter, korn, brød og pasta, ris, smør, margarin, nøtter, poteter, melk, egg og gatekjøkkenmat / burgere.

“Etter å ha tatt hensyn til forhold som skulle påvirke resultatene, viste analysen at hurtigmat var den eneste av  mat som gjorde utslag og påviste de samme resultatene på tvers av begge aldersgruppene, slo forfatterne fast at “slike konsistente resultater legger noen vekt på mulig årsakssammenheng av forholdet “.”

Tre eller flere ukentlige hurtigmatmåltider var blant annet knyttet til en 39 prosent økning i risikoen for alvorlig astma blant tenåringer og en 27 prosent økning i risiko blant barn. Forfatterne viser i rapporten at forklaringen kan være at hurtigmat inneholder høye nivåer av mettede fettsyrer og transfettsyrer, mens frukten er rik på antioksidanter.

Nyheter fra forskningen er hentet fra Astma Allergi Danmark

Les artikkelen på  The University of Auckland: Fast food linked to asthma and eczema

Dette er godt nytt for alle som vil ha en bedre helse. Dette leste jeg om på en engelsk side for en måned siden. Det er mange år siden jeg sluttet å spise hamburgere og slik mat. Jeg besluttet meg for på 1990 tallet å ikke spise så masse hurtigmat, hamburgere og slik. Nå blir det kanskje en eller to slike måltider i året. Ofte synes jeg ikke hamburgere er så veldig delikate heller. Det er få kiosker som er gode til å lage gode hamburgere. McDonalds og slike kjeder for eksempel lager uattraktiv mat og jeg har ikke spist på McDonalds på veldig mange år. Jeg går heller på en kafe eller restaurant og tar meg et ordentlig måltid.

 In English

Asthma Allergy Denmark 05.08.2013. News about Asthma Research

Fastfood increases the risk for severe asthma, rhinitis and eczema

It it does not come as any news to most people that fastfood is unhealthy, but that it can increase the risk of asthma, rhinitis and eczema may be news for most people?

A large international study from The University of Auckland (The two principal authors, Professor Innes Asher and Philippa Ellwood) shows that there is an increased risk of severe asthma, eczema and hay fever symptoms (rhinitis) in children and adolescents who eat fast food three or more times a week. Do you eat fruit, however three or more times a week may protect against severe asthma.

The study concludes that if the observed correlation is found to be reliable, so the results are of great importance to public health due to the increasing consumption of fast food globally.

There was collected data on more end 319,000 teenagers (13-14 years old) from 107 centers in 51 countries and more than 181,000 children (6-7 years) from 64 centers in 31 countries. The survey asked about participants’ intake of meat, fish, fruit and vegetables, legumes, cereals, bread and pasta, rice, butter, margarine, nuts, potatoes, milk, eggs and junk food / burgers.

Three or more weekly fast food meals was partly due to a 39 percent increase in the risk of severe asthma among teens and a 27 percent increase in risk among children.

“After taking account of factors likely to influence results, the analysis showed that fast food was the only food type to show the same associations across both age groups, prompting the authors to suggest that “such consistency adds some weight to the possible causality of the relationship”.”

The authors of the report shows that the explanation could be that fast food contains high levels of saturated fatty acids and trans fatty acids, while the fruit is rich in antioxidants.

News from research provided by Asthma Allergy Denmark

Read the story at  The University of Auckland: Fast food linked to asthma and eczema

This is good news for all who want a better health. This I read about on an English page about a month ago. It is many years since I stopped eating hamburgers and such food. I decided on that in the 1990s not to eat so lots of fast food, hamburgers and such. Now it’s maybe one or two such meals a year. Often I do not think hamburgers are so very delicate food either. There are few fast Food stores that are good at making good tasty hamburgers. McDonalds and such chains make unattractive food and I have not eaten at McDonalds for very many years. I rather go to a cafe or restaurant and have a proper meal.

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Research Virus, Asthma and Allergy breakthrough

(Scroll down for English)

Virus og allergi gjennombrudd

Hunter Medical Research Institute (HMRI) er partnerskap mellom Hunter New England Helse, Universitetet i Newcastle og Universitetet for helse og medisinsk forskning i Australia. Barne- og lungeforskere fra University of Newcastle, sammen med nasjonale Universitet og University of New South Wales, University of Cincinnati og Imperial College London, nærmer seg å identifisere kilden til alvorlige virus-og allergen-induserte astmaattakker etter å ha oppdaget at viktige molekylære signaler genereres veldig tidlig i sykdomsprosessen. De har jobbet med å undersøke mekanismer som utløser luftveibetennelse som forårsaker astmaanfall.

Studien var rettet mot forkjølelses rhinovirus, som er viruset som forårsaker de fleste astmaanfall, og effektene forårsaket av allergener som husstøvmidd.

To tredeler av astmaattakkene er forårsaket av virus. Astmatikere opplever alvorlige og langvarige symptomer når infisert med forkjølelsesvirus eller utsatt for allergener, som begge fremmer betennelser i lungene og produksjon av slim. Virus-induserte astmabesvær er langt mindre mottakelig for dagens behandlingsformer, derfor er denne oppdagelsen så viktig.

En omfattende genekspresjonsanalyse førte til oppdagelsen av proteinene ellers kjent som midtlinjen 1 og protein fosfatase 2A generert på det aller innerste laget av luftveiene, hvor kroppen har kontakt først med allergener og virus, og når aktivert synes å modulere mange andre sykdom faktorer. Det viser at det er mulig å beskytte mot utvikling av både virus-og allergen-indusert astma.

Forskningen viser at det UNSW utviklet forbindelse er i stand til å aktivere et protein som er undertrykt under astma. Dette kan bety at i fremtiden legene ville være i stand til å behandle årsaken til astma, ikke bare symptomene.

Astma er en av de store sykdommer i den utviklede verden. Det er svært sjelden å finne et stoff som kan reversere symptomer på astma. Det startet med dem arbeider på en forbindelse i behandlingen av akutt myeloid leukemi.

Det viktige med denne forbindelsen er at det er ikke bare lindre symptomene, men også den underliggende sykdommekanisme, en teamleder ved UNSW er Lowy Cancer Research Centre.

Forskning publisert i Nature Medicine verdens ledende tidsskrift for biomedisinsk forskning.

Hele historien på
HMRI og Science Alert

In English

Virus and allergy breakthrough

Hunter Medical Research Institute (HMRI) is partnership between Hunter New England Health, the University of Newcastle and the community for health and medical research in Australia. Paediatric and respiratory researchers from the University of Newcastle, along with national and University of New South Wales, the University of Cincinnati and the Imperial College London, are getting closer to identifying the source of serious virus-and allergen-induced asthma attacks after detecting important molecular signals generated very early in the disease process. They have worked investigating the mechanisms that trigger airway inflammation and cause asthma attacks.

The study targeted the common cold rhinovirus, which is the virus that causes most asthma attacks and the effects caused by allergens such as house dust mites.

Two-thirds of asthma attacks are caused by viruses. Asthmatics experience severe and prolonged symptoms when infected with the common cold virus or exposed to allergens, both of which promote inflammation in the lungs and production of mucus. Virus-induced effects are much less responsive to current therapies, which is why this investigation is so important.

A comprehensive gene expression analysis led to the discovery of the proteins otherwise known as midline 1 and protein phosphatase 2A generated in the innermost layer of the airways, where the body has first contact with allergens and viruses, and once activated they appear to modulate many other disease factors.  It show that it is possible to protect against the development of both virus- and allergen-induced asthma.

The research shows that the UNSW-developed compound is able to activate a protein that is suppressed during asthma. This could mean that in the future doctors would be able to treat the cause of asthma, not just the symptoms.

Asthma is one of the major diseases of the developed world. It’s very rare to find a compound that can reverse the symptoms of asthma. It started with them working on a compound in the treatment of acute myeloid leukaemia..

The important thing with this compound is that it’s not just alleviating the symptoms, it’s hitting at an underlying disease mechanism,a team leader at UNSW’s Lowy Cancer Research Centre.

Research published in  Nature Medicine the world’s leading journal for biomedical research.

The whole story on
HMRI and Science Alert

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Smoking Bans Reduce Hospitalizations: Study

Smoking Bans Reduce Hospitalizations: Study

MONDAY, Oct. 29 (HealthDay News) Significant cuts seen in heart attacks, strokes, asthma


“Bans on smoking in public areas and workplaces have significantly reduced hospitalizations for heart attacks, strokes and asthma around the world, a new study finds.

Researchers found that “smoke-free laws” in 33 locales led to a 15 percent reduction in hospitalizations for heart attack and a 16 percent reduction in hospitalizations for strokes.

Smoking bans also cut hospitalizations for asthma and chronic obstructive pulmonary disease and other respiratory diseases by 24 percent.

Smoke-free laws have dramatic and immediate impacts on health and the associated medical costs, says director of the Center for Tobacco Control Research and Education at the University of California, San Francisco.

To gauge the effectiveness of smoking bans, Glantz and study co-author Crystal Tan reviewed 45 studies that looked at smoke-free laws in the United States and around the world. Countries included such diverse places as Uruguay, New Zealand and Germany. This type of study is called a meta-analysis. In such a study, researchers hope to find a common pattern that may not be apparent from a single research project.

The largest decreases in hospitalizations were seen in areas with the most restrictive policies — for instance, those that ban smoking in workplaces, restaurants and bars. More comprehensive laws have bigger effects. Less comprehensive laws were associated with more hospitalizations. The study indicates that exceptions in indoor air laws send more people to the emergency room and lead to unnecessary and substantial medical costs for the patients, their employers and taxpayers.”

End Qoute

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New kinds of asthma treatment

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“Det er mange forskjellige versjoner av sykdommen astma. Og det er et behov for å utvikle nye typer medikamenter.

Ifølge Dr. C. Porsbjerg for Lungesykdommer Medicine avdeling på Bispebjerg Hospital har man tradisjonelt oppfattet astma som en enkelt sykdom som skal behandles på samme måte for alle rammede. Men i de senere årene har internasjonal astmaforskning malt et bilde av en sykdom som har mange forskjellige sykdomsmekanismer og symptomer.  Den nyeste forskningen er derfor rettet mot å beskrive de ulike undergruppene (fenotyper) av astma pasienter for å målrette behandlingen mer mot den enkelte pasients behov. Les: Hva er astma?

Kortikosteroider / binyrebarkhormon fungerer ikke for alle da luftveiene kramper. Behandlingen virker på de fleste pasienter, men det er også en betydelig gruppe som ikke har effekt: superintendent sier at ved ca. 30 prosent av astma pasienter virker ikke kortikosteroider. Hvorfor vet forskere ikke nokk om.

Nye behandlinger er på vei som kan være til nytte for de 30 prosent av pasientene der dagens behandling ikke fungerer – og det kan også ha færre bivirkninger.”

Og det liker vi, ikke sant? :)

Kilde / Sitat fra:

In English

“There are many different versions of the disease asthma. And there is a need to develop new types of drugs.

According to Dr. Pors Bjerg of Pulmonary Medicine Department at Bispebjerg Hospital have traditionally perceived asthma as a single disease to be treated the same for all affected. But in recent years, the international asthma research painted a picture of a disease that has many different mechanisms of disease and symptoms. The latest research is aimed at describing the various subgroups (phenotypes) of asthma patients to target therapy more towards the individual patient’s needs. Read: What is asthma?

Corticosteroids do not work for everyone when airway spasms. The treatment works for most patients, but there is also a significant group who do not have power: Superintendent says that by ca. 30 percent of asthma patients do not work corticosteroids. Why do scientists do not nokk about.

New treatments are on the way that may be of benefit to the 30 percent of patients whose current treatment is not working – and it may have fewer side effects. ”

And we like that, right? :)

Source / Qoute from:

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Chemical exposure a danger to childrens breating ability – studies confirm

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“To nye studier viser at utallige barn kan lide av pusteproblemer på grunn av noen av disse vanlige kjemiske truslene. Forskere fra Columbia Center for Children Environmental Health (CCCEH) ved Mailman School of Public Health og Columbia University Medical Center har fastslått at ungdommene som er eksponert under graviditeten av kjemikalier mye brukt i plantevernmidler additiv piperonylbutoksid (PBO) har en økt risiko for utvikle en kronisk hoste i alderen 5 – 6. Deres studie publisert i Miljø International, gir bevis for at et barns luftveier er utsatt for skader fra giftige eksponeringer mens de fortsatt i livmoren. En kronisk barndomhoste kan alvorlig forstyrre aktiviteter på dagtid og søvn.

En enda mer alvorlig problem forårsaket av vanlige kjemikalier som påvirker barnas evne til å puste fritt har blitt avslørt av en ny CCCEH studie. Ungdommer utsatt for dietylftalat (DEP) og butylbenzyl ftalat (BBzP), som er ftalat kjemikalier som vanligvis finnes i personlig pleie og plastprodukter, har en forhøyet risiko for astma-relaterte luftveibetennelser.

Forskerne studerte 244 barn mellom alderen 5 – 9 og fant de alle hadde påvisbare nivåer av ftalater i urinen. De med de høyere nivåer av begge ftalater ble funnet å ha høyere nivåer av nitrogenoksid i deres utåndet pust som er en biologisk markør for luftveisinflammasjon. Koblingen mellom BBzP eksponering og luftveibetennelse var spesielt sterk blant barn som nylig hadde opplevd piping i brystet, et vanlig symptom på astma.

Mens mange faktorer bidrar til barnastma, viser studier at eksponering for ftalater kan spille en betydelig rolle, “sier A. Just, PhD, førsteforfatter på studien. Studien er publisert online: American Journal of  Respiratory and Critical Care Medicine.”

In English

“Two new studies reveal countless children could be suffering breathing problems  due to some of these common chemical threats. … Researchers from the Columbia Center for Children’s Environmental Health (CCCEH) at the Mailman School of Public Health and Columbia  University Medical Center have determined that youngsters exposed during the prenatal period to the widely used pesticide additive piperonyl butoxide (PBO)  have an increased risk of developing a chronic cough at ages 5 and 6. Their  study published in Environment International, provides evidence that a child’s respiratory system is  susceptible to damage from toxic exposures while still in the womb. A chronic childhood cough can seriously disrupt daytime activities and sleep.

An even more serious problem caused by common chemicals that impact children’s ability to breathe freely has been revealed by another new CCCEH study. Youngsters exposed to diethyl phthalate (DEP) and butylbenzyl phthalate (BBzP), which are phthalate chemicals commonly found in personal care and plastic products, have an elevated risk of asthma-related airway inflammation.

The researchers studied 244 children between of ages 5 and 9 and found they all had detectable levels of phthalates in their urine. Those with the higher levels of both phthalates were found to have higher levels of nitric oxide in their exhaled breath that is a  biological marker of airway inflammation. The link between BBzP exposure and airway inflammation was especially strong among children who had recently experienced wheezing, a common symptom of asthma.

While many factors contribute to childhood asthma, the studies shows that exposure to  phthalates may play a significant role,” says A. Just, PhD, first author on the study. Study is published online: American Journal of  Respiratory and Critical Care Medicine.”


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Immune effects of respiratory exposure to fragrance

I found a research I want to share. Already in year 2007 they found that fragranced products can affect the immune system, respiration and give respiratory diseases and allergy. They found this out the same year I got my asthma, from secondhand smoking and fragranced washing agents used at work.

“Inhalation of the fragrance chemicals, isoeugenol and cinnamal (Isoeugenol (purity >99%) and cinnamal (purity >98%)), by mice resulted in immune reactions in the respiratory tract. This was observed in experiments performed by the RIVM (National Institute for Public Health and the Environment) of which results indicate that inhalation of some fragrance chemicals could induce unwanted effects on the immune system.

Fragrance chemicals are common ingredients in such consumer products as cosmetics and scented products. Several fragrance chemicals are known to cause allergy after skin exposure, but it is unknown whether inhalation of these fragrance chemicals can cause allergic reactions or other unwanted immune reactions. Till recently, it was assumed that inhalation of fragrance chemicals was harmless for humans, because there was no exposure via inhalation. However, applying fragrance chemicals in scented products used indoors, has changed this.

RIVM investigated the effects of inhalation of isoeugenol and cinnamal, fragrance chemicals that can cause skin allergy. Mice were exposed to the fragrance chemicals via inhalation. Effects on the immune system were measured using a respiratory lymph node assay, which measures cell proliferation in lymph nodes of the respiratory tract. Inhalation of both isoeugenol and cinnamal resulted in stimulation of the immune system of the respiratory tract. The effects of isoeugenol were more pronounced than those of cinnamal. This is in contrast with results observed after skin exposure, after which both these fragrance chemicals were found equally potent in inducing skin allergy. This implies that effects of fragrance chemicals on the immune system depend on the route of exposure.

washing powders, and scented products to improve the smell in homes, offices, cars and stores. The last category contains many different products, for example bathroom sprays, incenses, fragrant candles, and room perfumes. Exposure to fragrance chemicals used in scented products is predominantly via inhalation. For some applications, such as room perfumes, this exposure is chronic, while for others, for instance bathroom sprays, exposure is now and then.

Skin exposure to certain fragrance chemicals can induce contact allergy. The EU Scientific Committee on Consumer and Non Food Products (SCCNFP) has compiled a list with 24 fragrance chemicals that are most frequently reported as contact allergens.

For safety evaluation of fragrance chemicals the major route of exposure is considered to be the dermal route. Currently, exposure via inhalation in safety evaluations this route is not included. However, consumers can also be exposed via inhalation.

2007 TNO (Netherlands Organisation for Applied Scientific Research) together with the RIVM has developed a mouse model to assess the respiratory sensitizing potential of chemicals. In this model mice were exposed via the respiratory route on three consecutive days.

The immune response was determined by measuring cell proliferation and cytokine responses in the lymph nodes draining the respiratory tract. In this model, the most pronounced effects were found in the mandibular lymph nodes, which drain the nasopharynx.

To expose mice to these fragrance chemicals two methods of distribution were used: vaporization with maximum vapour pressure or nebulization of aerosols in acetone. Isoeugenol and cinnamal are known human skin sensitizers.

Mice were exposed noseonly to either isoeugenol or cinnamal for 45, 90, 180 or 360 minutes per day on day 0, 1 and 2. Controls were exposed to the vehicle for 360 minutes per day on day 0, 1, and 2. Mice were exposed to the fragrances either via evaporized or via nebulized test material.

Exposure to aerosols of isoeugenol (300 ppm) resulted in toxic effects in the mice that were exposed for 360 min/day. After two days of exposure one mouse died and the other mice displayed several signs of distress. These mice were not exposed to isoeugenol on the third day. Effects of the two days exposure to isoeugenol were assessed on day 5. On the third day two mice died that were exposed for 180 minutes/day for 3 days. The other mice in this group appeared normal.

Toxic effects were also observed after nose-only exposure to aerosols of cinnamal (300 ppm). Two mice died after exposure to cinnamal for 360 minutes/day for 1 day. The other mice in this group displayed several signs of distress.

The fragrance chemicals, isoeugenol and cinnamal, two known skin sensitizers, have been tested in the respiratory lymph node assay to assess their effects on the immune system after respiratory exposure.

The substance is delivered as a mixture of vapour and liquid droplets that will at least lead to local high dose levels due to impaction of the pure substance on respiratory tract epithelium. The size of the droplets (~ 5 μm) prevents them to reach the lower airways and alveoli, though once deposited, the compound can continue to evaporate resulting in significantly higher concentrations in the alveolar air spaces.

Immune reactions caused by chemicals in the lung can also induce other pulmonary reactions. Some chemicals induce a Th1-type immune responses in the lungs, as has been shown in rodent models. Skin allergens such as DNCB (dinitro-chloro-benzene), DNFB (dinitrofluoro-benzene) and picryl chloride were able to induce allergic reactions in the lungs, e.g. laryngitis, pneumotis, and airway hyperreactivity to non-specific stimuli.”  –, RIVM 2007 ‘National Institute for Public Health and the Environment’.

In this pilot research project from 2007 of respiratory exposure of fragrance some of the mice died from inhaling the fragrance chemicals. Even though this research is not ended, and more research is needed to be done it is remarcable that what people spray on themselves, smear on themselves, wash their clothes with, and wash their homes with, fragranced candles, airfresheners and any product holding fragrance can kill mice when they inhale fragrance after only 2 – 3 days.

Something to think about.